Cecropia pachystachya Trécul: a promising ingredient for skin-whitening cosmetics

Because it promotes the lightening of pigment spots, tyrosinase inhibition is one mechanisms depigmenting cosmetic products. Considering adverse effects produced by synthetic actives, search for new therapeutic options desirable, and plant extracts are possible candidates hyperpigmentation treatment. Glycolic Cecropia pachystachya Trécul are, therefore, focus this study. Its chemical characterization, antioxidant activity, inhibition, cell viability were evaluated. obtained macerating leaves C. in grain alcohol glycerin or propylene glycol. Both had a similar constitution, being more efficient concentrating phenolic compounds flavonoids. Analyses UHPLC-MS detected quinic acid, chlorogenic acid isomers, proanthocyanidin dimers type B C, catechin/epicatechin, orientin/isoorientin, isoorientin 2”-O-xyloside, vitexin/isovitexin, rutin. 5-O-caffeoylquinic was then quantified quantified, with predominance extract These showed high capacity method DPPH, β-carotene, nitric oxide. As both able to inhibit tyrosinase. Cell assay also revealed that could safely be used concentrations ≤ 125 µg/mL. Thus, study demonstrated first time glycolic have promising biological characteristics development multifunctional tyrosinase-inhibition activities.